Normal cell in negative UroVysion FISH test. Note two copies (signals) each of chromosome (Ch) 3 (CEP 3, Red), Ch 7 (CEP 7, Green), Ch 17 (CEP 17, Aqua), and locus specific probe for 9p21 (site of p16; LSI 9p21, Gold). |
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Abnormal cell in positive UroVysion FISH test. Polysomy is clearly demonstrated, with five copies of Ch 3 (CEP 3, Red), three copies of Ch 7 (CEP 7, Green), and four copies of Ch 17 (CEP 17, Aqua). Loss of one copy of 9p21 is also noted (LSI 9p21, Gold). |
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UroVysionTM (Vysis): monitoring for recurrence and initial diagnosis of bladder carcinoma
MOD Lab incorporates ThinPrep technology (CYTYC) and automated image analysis (Applied Imaging, Inc; BioView Duet) for > 97 % diagnostically informative and objective results
MOD Lab personnel and affiliated laboratories have extensive experitise in urine cytology and urine diagnostics and have been innovators in correlating urine cytology diagnoses with FISH
Recent studies support “reflex FISH” in patients with atypical or suspicious cytology and allowing for more cost effective management of bladder cancer patients |
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PathVysion® (Vysis): detection of HER-2/neu gene amplification in breast carcinoma
Extensive experience in breast cancer surgical pathology sign out, ensuring the correct foci are analyzed
Rapid turnaround time
Scanned Her-2 immunohistochemistry available for future correlative quantitative image analysis
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HEME Path FISH
t(11;14) LSI IGH/CCND1 XT - FISH (including in paraffin sections)
t(14;18) IGH/BCL2 - FISH
t(8;14) IGH/MYC/CEP 8 - FISH
LSI MYC DC BAR - FISH
BCR/ABL DF t(9;22) - FISH
t(15;17) PML/RARA DF - FISH
MDS panel FISH
Multiple Myeloma panel FISH
CLL panel FISH |
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Basic and Clinical Research FISH |
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Representative cells from positive PathVysion FISH case, with amplification of the HER-2/neu gene. Probe signals for HER-2/neu (LSI, Orange) and chromosome (Ch) 17 (CEP 17, Green) imaged in three DAPI-stained nuclei of invasive ductal carcinoma in formalin-fixed paraffin-embedded section. Left to right: cell with 5 copies HER-2/neu, 2 copies Ch 17; cell with 2 copies HER-2/neu, 2 copies Ch 17; cell with 5 copies HER-2/neu, 1 copy Ch 17. |
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Number of clinical FISH cases performed per month by MOD Lab personnel in 2004 and 2005. |
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